Epithalamin Increases the Lifespan of Fruit Flies, Mice and Rats
Anisimov VN, Khavinson VK, Provinciali M, Alemi M, Franceschi C
Mechanisms of Ageing and Development · Vol. 127(7) · pp. 556–561 · 2006
Multi-species study demonstrating that Epithalon (Epithalamin) extends lifespan in Drosophila, mice, and rats. The peptide activates telomerase, maintains telomere length, and regulates circadian rhythms through pineal gland modulation. This study provides the foundational evidence for Epithalon's anti-aging properties.
Citation
Key Findings
Extended mean lifespan by 13–16% in Drosophila melanogaster
Increased maximum lifespan in mice and rats by 10–25%
Activates telomerase and maintains telomere length in somatic cells
Regulates melatonin production and circadian rhythm function
Reduces incidence of spontaneous tumors in aging rodents
Methodology
Longitudinal lifespan studies in three species (Drosophila, mice, rats) with Epithalon administered via injection. Includes telomere length analysis and tumor incidence monitoring.
Limitations
Animal model data only; no human lifespan data available. Mechanism of telomerase activation not fully elucidated.
Protocols Using This Research
Tags
Educational use only. Research summaries are provided for informational purposes. Always consult the original publication and a qualified healthcare provider before making clinical decisions.
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