BPC-157
Body Protection Compound-157
A synthetic pentadecapeptide derived from a protective protein found in gastric juice. Widely studied for its remarkable tissue-healing and anti-inflammatory properties.
Quick Reference
Mechanism of Action
BPC-157 upregulates growth hormone receptors, promotes angiogenesis (new blood vessel formation), and modulates nitric oxide synthesis. It accelerates the healing of tendons, ligaments, muscles, and the gastrointestinal tract by activating the FAK-paxillin pathway and stimulating VEGF expression.
Health Claims & Evidence
Accelerates tendon and ligament healing
Reduces systemic inflammation
Supports gut lining repair and leaky gut
May support joint health and cartilage repair
Neuroprotective and mood-modulating effects
Short-Term Effects
Reduced pain and inflammation at injury sites, improved gut comfort, faster wound closure. Most users report noticeable effects within 1–2 weeks.
Long-Term Effects
Sustained tissue repair, potential for improved joint resilience. Long-term human safety data is limited; most evidence is from animal models.
Side Effects
Generally well-tolerated in studies. Reported side effects are rare and include mild nausea and dizziness. No serious adverse events documented in research literature.
Contraindications
Not recommended during pregnancy or for individuals with active cancer (due to angiogenic properties). Consult a physician before use.
Dosage Notes
Subcutaneous injection near the injury site is the most studied route. Oral dosing requires higher amounts due to reduced bioavailability.
Sourcing Notes
Available as a research peptide from licensed compounding pharmacies. Purity and sterility vary significantly between suppliers — third-party testing (HPLC, mass spectrometry) is essential.
Research Papers
Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease
Sikiric et al. · Current Pharmaceutical Design · 2016
BPC 157 and tendon healing
Chang et al. · Journal of Applied Physiology · 2011
Cytoprotective effect of BPC 157 on gastric mucosa
Sikiric et al. · Digestive Diseases and Sciences · 1993
Educational use only. This profile is for informational purposes and does not constitute medical advice. Consult a qualified healthcare provider before beginning any peptide protocol.
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