Epithalon
Epithalamin / Epitalon
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland peptide Epithalamin. Studied extensively in Russian research for its telomere-lengthening and anti-aging properties.
Quick Reference
Mechanism of Action
Epithalon activates telomerase — the enzyme responsible for maintaining and lengthening telomeres, the protective caps on chromosomes that shorten with age. It also regulates melatonin production via the pineal gland, normalizes circadian rhythms, and has demonstrated antioxidant and anti-tumor properties in animal studies.
Health Claims & Evidence
Activates telomerase and may lengthen telomeres
Normalizes circadian rhythms and improves sleep
Extends lifespan in animal models
Antioxidant and anti-tumor properties
Short-Term Effects
Improved sleep quality and depth, increased energy, enhanced sense of wellbeing. Effects on circadian rhythm often noticed within the first cycle.
Long-Term Effects
Potential telomere maintenance and anti-aging effects with repeated cycles. Long-term human data is limited but the safety profile appears favorable.
Side Effects
Very well tolerated in studies. No significant adverse effects reported at standard doses.
Contraindications
Limited data in pregnancy. Theoretical caution with active malignancy given cell proliferation effects. Consult a physician.
Dosage Notes
The classic protocol from Russian research uses 10 mg/day for 10 days, twice yearly. Some practitioners use shorter cycles more frequently.
Sourcing Notes
Available from research peptide suppliers. Relatively stable compound. Verify purity via third-party testing. Store refrigerated.
Research Papers
Epithalamin increases the lifespan of fruit flies, mice and rats
Anisimov et al. · Mechanisms of Ageing and Development · 2006
Pineal peptide preparation epithalamin activates telomerase
Khavinson et al. · Neuroendocrinology Letters · 2003
Educational use only. This profile is for informational purposes and does not constitute medical advice. Consult a qualified healthcare provider before beginning any peptide protocol.
Often Stacked With
Want a personalized protocol?
Our AI Advisor will incorporate Epithalon into a complete stack tailored to your goals and health context.
Start Assessment