TB-500
Thymosin Beta-4 (synthetic fragment)
A synthetic version of the naturally occurring peptide Thymosin Beta-4, found in virtually all human and animal cells. Plays a central role in cell migration, proliferation, and tissue repair.
Quick Reference
Mechanism of Action
TB-500 works by upregulating actin — a protein essential for cell structure and movement. It promotes endothelial cell differentiation, angiogenesis, and reduces inflammation by blocking the activity of inflammatory cytokines. Its systemic distribution allows it to travel to sites of injury throughout the body.
Health Claims & Evidence
Promotes muscle fiber repair and growth
Improves flexibility and reduces scar tissue formation
Systemic healing — reaches distant injury sites
Supports cardiac tissue repair
Short-Term Effects
Reduced inflammation and pain, improved range of motion, accelerated recovery from acute injuries. Effects typically noticed within 2–4 weeks.
Long-Term Effects
Improved tissue quality and reduced scar tissue over extended use. Long-term human data is limited.
Side Effects
Generally well-tolerated. Some users report temporary lethargy or head rush post-injection. Theoretical concern around angiogenic properties in cancer contexts.
Contraindications
Avoid with active malignancy due to angiogenic activity. Not for use during pregnancy. Consult a physician.
Dosage Notes
Often stacked with BPC-157 for synergistic recovery effects. The loading/maintenance protocol is common in the research community.
Sourcing Notes
Widely available as a research peptide. Quality varies — seek suppliers with published HPLC certificates of analysis. Often sold as lyophilized powder requiring reconstitution with bacteriostatic water.
Research Papers
Thymosin beta4 accelerates wound healing
Philp et al. · Annals of the New York Academy of Sciences · 2004
Thymosin beta-4 and cardiac repair
Bock-Marquette et al. · Nature · 2004
Educational use only. This profile is for informational purposes and does not constitute medical advice. Consult a qualified healthcare provider before beginning any peptide protocol.
Often Stacked With
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