Ipamorelin
Ipamorelin
A selective growth hormone secretagogue and ghrelin receptor agonist. Considered one of the cleanest GH-releasing peptides due to its high selectivity and minimal side effects.
Quick Reference
Mechanism of Action
Ipamorelin mimics ghrelin and binds to the GHS-R1a receptor in the pituitary gland, stimulating a pulsatile release of growth hormone. Unlike other GHRPs, it does not significantly raise cortisol or prolactin, making it highly selective for GH release.
Health Claims & Evidence
Stimulates natural growth hormone release
Improves body composition — reduces fat, increases lean mass
Enhances sleep quality and recovery
Anti-aging effects on skin, bone density, and connective tissue
Short-Term Effects
Improved sleep depth, increased energy, mild appetite stimulation. GH pulse elevation detectable within hours of administration.
Long-Term Effects
Gradual improvements in body composition, skin quality, and recovery capacity over 8–12 week cycles.
Side Effects
Generally very well tolerated. Mild water retention possible. Occasional headache or flushing. No significant cortisol or prolactin elevation.
Contraindications
Use with caution in individuals with insulin resistance or diabetes (GH can affect insulin sensitivity). Not for use during pregnancy.
Dosage Notes
Commonly stacked with CJC-1295 (without DAC) for synergistic GH release. Administer on an empty stomach for best results.
Sourcing Notes
Available from research peptide suppliers. Requires cold storage (refrigeration). Reconstitute with bacteriostatic water. Verify purity via HPLC certificate.
Research Papers
Ipamorelin, the first selective growth hormone secretagogue
Raun et al. · European Journal of Endocrinology · 1998
Growth hormone secretagogues and body composition
Nass et al. · Journal of Clinical Endocrinology & Metabolism · 2008
Educational use only. This profile is for informational purposes and does not constitute medical advice. Consult a qualified healthcare provider before beginning any peptide protocol.
Often Stacked With
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