Semax
Semax (ACTH 4-7 Pro-Gly-Pro)
A synthetic heptapeptide analogue of ACTH (adrenocorticotropic hormone) developed in Russia. Widely used for cognitive enhancement, neuroprotection, and mood regulation.
Quick Reference
Mechanism of Action
Semax increases BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) expression, promoting neuronal survival and synaptic plasticity. It modulates dopaminergic and serotonergic systems and has demonstrated neuroprotective effects in stroke and ischemia models.
Health Claims & Evidence
Increases BDNF and supports neuroplasticity
Enhances focus, memory, and cognitive performance
Neuroprotective in stroke and ischemia
Mood enhancement and anxiolytic effects
Short-Term Effects
Increased mental clarity, focus, and motivation within hours of administration. Mood elevation common.
Long-Term Effects
Potential for sustained neuroplasticity improvements and neuroprotection with cycling use. Tolerance may develop with continuous use.
Side Effects
Generally well tolerated. Possible mild anxiety or overstimulation at higher doses. Nasal irritation with intranasal route.
Contraindications
Use with caution in individuals with anxiety disorders or bipolar disorder. Not for use during pregnancy.
Dosage Notes
Intranasal administration allows direct delivery to the brain via the olfactory pathway. Administer in the morning to avoid sleep disruption from stimulatory effects.
Sourcing Notes
Available as nasal spray or injectable from research suppliers. Nasal spray formulations vary in concentration. Verify purity and sterility.
Research Papers
Semax and BDNF expression in the rat brain
Dolotov et al. · Journal of Neurochemistry · 2006
Clinical use of Semax in cerebrovascular disease
Gusev et al. · Zhurnal Nevrologii i Psikhiatrii · 1997
Educational use only. This profile is for informational purposes and does not constitute medical advice. Consult a qualified healthcare provider before beginning any peptide protocol.
Often Stacked With
Want a personalized protocol?
Our AI Advisor will incorporate Semax into a complete stack tailored to your goals and health context.
Start Assessment