Selank
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro)
A synthetic analogue of the human tetrapeptide tuftsin, developed in Russia. Primarily studied for its anxiolytic, nootropic, and immune-modulating properties without sedation.
Quick Reference
Mechanism of Action
Selank modulates the expression of BDNF and serotonin transporter genes, stabilizes enkephalins (endogenous opioid peptides), and influences IL-6 expression. It produces anxiolytic effects comparable to benzodiazepines without sedation, dependence, or withdrawal.
Health Claims & Evidence
Reduces anxiety without sedation or dependence
Enhances memory and learning
Immune system modulation
Stabilizes mood and reduces stress response
Short-Term Effects
Rapid anxiety reduction, improved mood, and mental clarity. Effects often felt within 20–30 minutes of intranasal administration.
Long-Term Effects
Potential for sustained mood stabilization and cognitive improvements with cycling. No dependence or withdrawal documented.
Side Effects
Excellent safety profile. Mild nasal irritation with intranasal use. No significant adverse effects in clinical studies.
Contraindications
Limited data. Use with caution alongside other anxiolytic or psychiatric medications. Consult a physician.
Dosage Notes
Often used situationally for acute stress or anxiety. Can be used alongside Semax for a balanced cognitive and mood stack.
Sourcing Notes
Available as nasal spray from research suppliers. Less widely available than Semax. Verify purity and concentration carefully.
Research Papers
Selank and anxiety: clinical trial results
Semenova et al. · Bulletin of Experimental Biology and Medicine · 2010
Selank modulates BDNF expression
Inozemtseva et al. · Doklady Biological Sciences · 2008
Educational use only. This profile is for informational purposes and does not constitute medical advice. Consult a qualified healthcare provider before beginning any peptide protocol.
Often Stacked With
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